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The ODBC (Open Database Connectivity) API provides operating system and platform-independent access to database management systems. InterSystems provides a fully compliant (ODBC 3.5) ODBC driver, which you can use to access HealthShare® Health Connect databases using ODBC. The driver is installed by default when you install Health Connect.

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Open Database Connectivity (Wikipedia)

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Connecting with the ODBC Driver

Native API for .NET