Python DB-API Support InterSystems supports the Python Database API specification with two different implementations: The InterSystems DB-API is a fully compliant implementation of PEP 249 version 2.0Opens in a new tab providing a direct interface to the InterSystems database. See Using the Python DB-API in Using the Native SDK for Python for more information. pyodbc is a third party open source Python module. InterSystems supports use of pyodbc as a way to access the database via the InterSystems ODBC driver. This module can also be used with versions of InterSystems IRIS earlier than 2022.1. See Support for pyodbc Python ODBC Bridge in Using the InterSystems ODBC Driver for more information.